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M94A3139.TXT
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1994-10-25
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Document 3139
DOCN M94A3139
TI Acute and sustained immunosuppression with HIV seroconversion.
DT 9412
AU Gupta KK
SO Int Conf AIDS. 1994 Aug 7-12;10(1):145 (abstract no. PB0006). Unique
Identifier : AIDSLINE ICA10/94369436
AB OBJECTIVE: Acute and sustained immunosupression with serious systematic
opportunistic infection can occur immediately after HIV seroconversion.
RESULTS: TABULAR DATA, SEE ABSTRACT VOLUME. CMV Colitis was confirmed by
biopsy, Immunoperoxidase stain and 10-fold increase in CMV IgG titer.
CONCLUSIONS: 1. HIV morbidity and mortality figures will become
proportionately worse with increased prevalence of this mutant strain.
2. DNA sequencing should be done on this strain, to find any exclusive
mutant sequence, responsible for excessive virulence. It should be
deleted or altered by genetic engineering to obtain possibly a benign
viral strain, which could be helpful for vaccine research.
DE Antibodies, Viral/BLOOD AIDS-Related Opportunistic
Infections/*IMMUNOLOGY Cytomegalovirus/IMMUNOLOGY/ISOLATION &
PURIF/PATHOGENICITY Cytomegalovirus Infections/IMMUNOLOGY CD4-CD8
Ratio Human HIV Antibodies/ANALYSIS HIV Seropositivity/*IMMUNOLOGY
IgG/BLOOD *Immune Tolerance *Leukocyte Count Morbidity T-Lymphocyte
Subsets/IMMUNOLOGY Virulence MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).